Additionally, brain cell type-specific altered expression of major genes involved in endothelial dysfunction in COVID-19 was observed, with KDR, NOS, TGFB1, ICAM1, EDN1, PROCR, ANGPT2, and PDGFB upregulated in endothelial cells of COVID-19 patients compared to the healthy control. This evidence concerns the gene ANGPT2 and endothelial dysfunction.