A key oncogenic driver of GBM is the receptor tyrosine kinase PDGFRA, which binds to its ligands PDGFA/B/C to trigger growth factor signaling and inhibition of mitophagy in oligodendroglial progenitor cell-like GBM stem cells, resulting in pro-neural GBM [72,84,85]. The gene discussed is PDGFRA; the disease is glioblastoma.