P2RX7 and status epilepticus: However, regarding whether P2X7 has proconvulsive or anticonvulsive effects that vary according to the animal models of status epilepticus, P2X7 plays proconvulsive roles in pilocarpine-induced status epilepticus and anticonvulsive roles in status epilepticus triggered by intra-amygdala injection of kainic acid [101,102].