Cluster analysis revealed that the combined impacts of ACE, relationship dissatisfaction, undesired pregnancy, PMS, and activated immunological profiles (including elevated levels of IL-4, IL-6, CXCL8, IL-12, IL-15, IL-17, and GM-CSF), as well as the resulting early depressive symptoms, define a new endophenotypic class. The gene discussed is CXCL8; the disease is premenstrual tension.