In a study with 61 depressed college students, the severity of depression and anxiety and the patterns of inflammatory factors, such as TNF-α, interleukin-6 (IL-6), and IL-1β, were determined after 6 weeks of moderate-to-high-intensity interval training, and reductions were demonstrated in depression severity and TNF-α level [13]. The gene discussed is TNF; the disease is major depressive disorder.