CREB1 and obstructive sleep apnea syndrome: Related research found that the SIRT1/CREB/BDNF signaling was involved in regulating the cognitive function of rats with obstructive sleep apnea syndrome (OSAS), and 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside improved the cognitive function and synaptic plasticity by activating the SIRT1/miR-134 pathway and regulating the expression of BDNF and CREB [83].