It has been found that the release of TNF-α stimulates the reuptake of 5-HT in rat embryonic raphe cell lines, rapidly activates the serotonin transporter (SERT) through the p38 mitogen-activated protein kinase (p38MAPK)-mediated signaling pathway and reduces the concentration of 5-HT leading to depression [14,15]. The gene discussed is TNF; the disease is depressive symptom measurement.