In conclusion, SIRT1 plays an important regulatory role in the process of exercise ameliorating depression by inhibiting the inflammatory response; that is, exercise can reduce the level of NF-κB protein in the brain, inhibit the pro-inflammatory response of TNF-α, IL-1β, and IL-6, and promote the anti-inflammatory response of IL-10 and TNF-β by upregulating SIRT1. Here, NFKB1 is linked to major depressive disorder.