Nanda et al. also showed that in screening for GDM at 11–13 gestation weeks by maternal characteristics in which maternal age, BMI, racial origin, previous history of GDM and macrosomic neonate were significant independent predictors of future GDM, the detection rate was 61.6% at a false-positive rate of 20% and the detection increased to 74.1% by the addition of adiponectin and SHBG which were also lower in their study in the GDM group [63]. This evidence concerns the gene SHBG and gestational diabetes.