CASP3 and ocular hypertension: This is in agreement with previous findings showing that treatment with Gangliomix is associated with a decreased activation of the apoptotic cascade, measured by the improved ratio of Bax/Bcl2 and the reduction in caspase-3 expression in a mouse model of optic nerve crush [34] and following the induction of ocular hypertension by methylcellulose (MCE) injection [35].