DRD2 and drug-induced dyskinesia: Levodopa (L-DOPA), the gold standard in treating PD, successfully reduces the major motoric symptoms, such as bradykinesia and tremor, after biotransformation to dopamine, subsequently activating the D2R. Problematically, L-DOPA (and dopamine, respectively) is also known to induce dyskinesia (L-DOPA-induced dyskinesia) due to the promiscuous activation of the D1R in long-term treatment conditions [10].