Other genetic polymorphisms associated with Alzheimer’s disease encompasses clusterin (CLU), sortilin-related receptor-1 (SORL1), complement component receptor 1 (CR1), ATP-binding cassette transporter A member 7 (ABCA7), fermitin family member 2 (FERMT2), major histocompatibility complex class II (HLA-DRB5, HLA-DRB1), bridging integrator 1 (BIN1), phosphatidylinositol-binding clathrin assembly molecule (PICALM), and aquaporin 4 (AQP4) [106,109,115,116,117]. The gene discussed is SORL1; the disease is early-onset autosomal dominant Alzheimer disease.