The physiological functions of sCLU, as shown by the studies mentioned above, are as follows: (i) stabilizing the Ku-70-Bax complex and suppressing Bax activation; (ii) promoting cancer cell survival via PI3K/AKT signaling; (iii) promoting autophagy and the angiogenesis of cancer; and (iv) enhancing cancer metastasis by promoting metalloproteinase expression. Here, BAX is linked to cancer.