SIRT1 and osteoporosis: This study found that RSV could counteract the molecular changes in aged male osteoporosis by decreasing inflammatory cytokines such as Il-1 β, Il-6, TNF-α, and RANKL, as well as oxidative stress markers such as MDA and nitric oxide (NO), and by increasing Forkhead box O1 (FoxO1), Sirt1, and OPG gene expressions [54].