Suppression of miR-92b-3p expression increased NADPH oxidase 4 (Nox4) and NF-κB levels, decreased Smad7, BMP2, and Runx2 gene and protein expressions, and inhibited bone marrow mesenchymal stem cell (BMSC) proliferation and osteoblast differentiation, resulting in more severe osteoporosis. The gene discussed is RUNX2; the disease is osteoporosis.