Previously, we demonstrated that both 5-amino salicylic acid (Mesalazine) and sodium salicylate (SS) exert beneficial effects in dextran sodium sulfate (DSS)-induced intestinal inflammation through activation of macrophage-specific AMPK β1 complexes [4], emphasizing the important role of macrophage AMPK in the regulation of intestinal inflammation. This evidence concerns the gene PRKAB1 and inflammation.