Furthermore, alterations of SDH genes have been described in various human diseases, including hereditary and sporadic tumors such as gastrointestinal stromal tumors [25,26,27], pheochromocytoma, paraganglioma, renal carcinomas and papillary thyroid carcinomas [28,29,30,31,32]. The gene discussed is SDHB; the disease is gastrointestinal stromal tumor.