Due to their demonstrated correlations with other metabolic parameters, such as blood pressure, lipid levels, IR, inflammation markers, weight change or food intake, adipokines, such as adiponectin, vaspin, resistin, chemerin, visfatin, BMP-7 and TNF-α, offer the potential to be used as predictive biomarkers for the clinical diagnosis and prognosis assessment of obesity-related imbalances. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.