ADIPOQ and Insulin resistance: - improved liver fat in patients suffering from NAFLD  - ↓ triglycerides and hepatic fat  - ↓ total cholesterol  - ↓ LDL-C  - ↓ insulin resistance  - ↓ bone-specific alkaline phosphatase  - ↓ procollagen type I N-terminal propeptide  - ↓ osteocalcin  - ↑ HDL-C  - ↑ adiponectin