Thus, in AD the accumulation of Aβ predominates, in Parkinson’s disease (PD) alpha (α)-synuclein aggregates are found more abundantly [74], while in amyotrophic lateral sclerosis (ALS), increased pathological accumulations of transactive response DNA binding protein 43 (TDP43) have been detected more recently [75]. Here, TARDBP is linked to amyotrophic lateral sclerosis.