Encephalitis, which may variably present with memory deficits, psychosis, and seizures, can be associated with antibodies to Hu/ANNA-1 or Ma2, suggesting underlying SCLC or testicular cancer, respectively, or can alternatively be associated with “intermediate-“risk (anti-GABABR, AMPAR) or “lower-risk” antibodies (anti-LGI1, CASPR2) [16]. The gene discussed is LGI1; the disease is viral encephalitis.