“Intermediate-” and “low-risk” syndromes, such as encephalitis and SPSD, can also be paraneoplastic, the former when associated with anti-Ri/ANNA-2 (breast cancer) or anti-Ma2 (testicular cancer) antibodies, and the latter when associated with anti-amphiphysin (SCLC) antibodies [26,59,63,114]. The gene discussed is AMPH; the disease is encephalitis.