ACTA1 and Hepatic fibrosis: Adoptive transfer of splenocytes (enriched with NK cells) from naive SCID mice (lacking B and T cells) that underwent iKIR knockdown by siRNAs can reduce CCl4-induced liver fibrosis in BALB/c male SCID-Beige mice (lacking B/T/NK cells), which is evidenced by reduced expression of collagen and α-SMA production [64].