Another study also showed that transcriptional factors such as IRF8 (interferon regulatory factor 8), NR4A2 (nuclear receptor subfamily 4 group A member 2), IKZF3 (IKAROS family zinc finger 3), and REL (REL proto-oncogene, NF-κB subunit) may be implicated in the roles of NK cells during liver fibrosis [58]. The gene discussed is IRF8; the disease is Hepatic fibrosis.