VEGFA and diabetic macular edema: On the same note, Boiko et al. investigated the retinal tissue area (RTA) and optical density (ODRT) of the retinal optical slice portion located in the central subfield, as well as their ratio (RTA/ODRT) in the presence of diabetic macular edema (DME) or of intraretinal cystic fluid (IRF) in neovascular age-related macular degeneration (nAMD) before and after anti-VEGF treatment [24].