IGHE and hematopoietic and lymphoid cell neoplasm: In a larger epidemiological study on the 2005–2006 National Health and Nutrition Examination Survey, the rate of prior malignancy, including breast, skin, uterine, cervical, lung, prostate, and hematologic cancer, was significantly higher in the IgE-deficient group (here defined as IgE levels below 2.5 kU/L) compared with individuals with high and very high IgE levels [57].