Considering that helminths are, by far, the most potent inducers of IgE [14], different ranges of normality for the total IgE are being used for helminth-free, Westernized populations (from a few to hundreds of nanograms per milliliter) [4,5] and for populations frequently exposed to helminth infections (from hundreds of nanograms per milliliter to dozens of micrograms per milliliter) [15]. The gene discussed is IGHE; the disease is helminthiasis.