Here, we show that in human CNS tissue, robust levels of STING are present and higher in the brain microvascular and neuronal cells of several NDs, including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD) and multiple sclerosis (MS), compared to non-neurodegenerative samples. Here, STING1 is linked to Alzheimer disease.