For instance, in glioma cells lncRNA SNHG5 is bound directly to miR-205-5p, thus preventing the inhibition of its endogenous target, ZEB2 [88]; in another study, lncRNA HOTAIRM1 activated ZEB2 expression by repressing miR-873-5p (a tumour suppressor) [89]. This evidence concerns the gene ZEB2 and central nervous system cancer.