Zhang et al. [95] showed that lncRNA HOTTIP expression level was positively correlated with HIF-1α in 116 glioma samples and that the high level of HOTTIP was correlated with metastasis when compared with a non-metastatic group (60 tumour tissues with metastasis vs. 56 tumour tissues without metastasis). The gene discussed is HIF1A; the disease is central nervous system cancer.