ITGAM and infection: A similar relationship between the morphology of neutrophils and their functional activity was described in [19], where the studied blood neutrophils of mice with different sensitivity to infection were divided into three subpopulations: (1) PMN-N (phenotype CD49d−, CD11b−, TLR-2,-4,-9, with round nuclei), not affecting macrophages; (2) PMN-I (phenotype CD49d+, CD11b−, IL-12, CCL3, TLR-2,-4,-5,-8, with multilobular nuclei), activating M1-macrophages; and (3) PMN-II (phenotype CD49d−, CD11b+, IL-10, CCL2, TLR-2,-4,-7,-9, with ring-shaped nuclei), activating M2-macrophages.