However, the authors reported a PD risk-conferring polymorphism in the SIRT2 gene and showed that a single nucleotide polymorphism (SNP) in this gene alters the binding efficiency of miR-486-3p to SIRT2, thereby increasing the expression level of SIRT2, which could increase α-synuclein aggregation and toxicity [187]. This evidence concerns the gene SIRT2 and Parkinson disease.