Interestingly, a variety of long non-coding RNAs (e.g., KCNMA1-AS1, AL592158.1, AC012146.1, IRAIN, A2M-AS1, PVT1, etc.), many of them probably involved in epigenetic control, were differentially expressed in patients with ARDS. The gene discussed is IRAIN; the disease is acute respiratory distress syndrome.