Various upregulated genes identified in ARDS control lipid metabolic functions (e.g., OLAH, PCSK9, ACBD7, LPL, FABP2), polyubiquitination (e.g., SCN5A, UBQLN4P1, GRB10), and metalloproteinases (e.g., ADAMTS3, TIMP4, MMP1, MMP8). This evidence concerns the gene MMP1 and acute respiratory distress syndrome.