PCSK9 and acute respiratory distress syndrome: Various upregulated genes identified in ARDS control lipid metabolic functions (e.g., OLAH, PCSK9, ACBD7, LPL, FABP2), polyubiquitination (e.g., SCN5A, UBQLN4P1, GRB10), and metalloproteinases (e.g., ADAMTS3, TIMP4, MMP1, MMP8).