Various upregulated genes identified in ARDS control lipid metabolic functions (e.g., OLAH, PCSK9, ACBD7, LPL, FABP2), polyubiquitination (e.g., SCN5A, UBQLN4P1, GRB10), and metalloproteinases (e.g., ADAMTS3, TIMP4, MMP1, MMP8). The gene discussed is GRB10; the disease is acute respiratory distress syndrome.