As in the CD8+ T cells, there was an increase in the CXCR3−CCR6− cell compartment, which occurred at the expense of T1-like cells (p > 0.05), and an augmentation of Tf-T17 (p < 0.05) and Tf-T1/17-like cells (p > 0.05), which was accompanied by a reduction in the Tf-T1 cell compartment (p > 0.05), in SSc CD4−CD8− TCRαβ T cells (Figure 9 and Table S1). The gene discussed is CD8A; the disease is systemic sclerosis.