Interestingly, under the influence of MSCs, the CD4+ T cells from the anti-Scl-70 SSc group were more prone to undergoing differentiation into Th17 (vs. HC and ACA SSc), while in the ACA SSc group, the presence of MSCs resulted in a decrease in Th1/17, Tc1, and Tc1/17 differentiation, while CD4+ Treg cells were induced and/or expanded (Table S1). This evidence concerns the gene CD4 and systemic sclerosis.