Like CD8+ T cells, CD4+CD8+ T cells’ polarization tended to be biased towards CXCR3−CCR6−, whereas the T1-like subset was depleted (p > 0.05); moreover, the percentage of CD4+CD8+ Tf-T1/17 cells was increased in SSc patients and, conversely, that of CD4+CD8+ Tf-T1 cells was decreased (p > 0.05). This evidence concerns the gene CD4 and systemic sclerosis.