In the same line, SSc CD8+ (CXCR5− non-Treg) T cells tend to by preferentially differentiated into CXCR3−CCR6− (a cell compartment comprising Tc2 cells) at the expense of the Tc1 compartment (p > 0.05), as detailed in Figure 6B and Table S1. The gene discussed is CXCR5; the disease is systemic sclerosis.