The authors noted that GLO1 KO melanoma cells displayed a shortened population doubling time, cell cycle alteration with increased M-phase population, and enhanced anchorage-independent growth, a phenotype supported by expression analysis, while confirming an earlier finding that GLO1 deletion limits invasion and metastasis with modulation of EMTrelated genes (e.g., TGFBI, MMP9, ANGPTL4, TLR4, SERPINF1) (CXCL8, CD24, IL1A, CDKN1A). The gene discussed is GLO1; the disease is melanoma.