In the presence of neoadjuvant therapy, some of these effects decrease in peritumoral AT; however, in patients with a poor response to treatment, the expression of factors involved in stemness, EMT, neo-angiogenesis and leptin signalling remains higher in comparison with patients with a better prognosis, suggesting that peritumoral adipose tissue may promote characteristics of the microenvironment that sustain the progression and chemoresistance of the tumour [122]. Here, LEP is linked to neoplasm.