In multiple myeloma, adipocyte-secreted Angiotensin II (ANG-II) directly stimulates acetyl-CoA synthetase 2 (ACSS2) in myeloma cells, contributing to obesity-induced myelomatous tumorigenesis, and the inhibition of the ANG-II-ACSS2 axis prevents obesity-induced tumour growth [120]. This evidence concerns the gene ACSS1 and obesity due to melanocortin 4 receptor deficiency.