LEP and neoplasm: For example, adiponectin, which promotes adipose tissue microenvironment homeostasis, acts locally on adipocytes to regulate glucose uptake, adipogenesis and lipid storage, whereas leptin, which promotes adipose tissue microenvironment dysfunction, regulates adipocyte lipolysis, producing adipocyte-derived lipids that are transferred to tumour cells to induce metabolic reprogramming, growth and invasion [87].