Additionally, mutations of the ciliary protein inversin, which inhibits the canonical β-catenin depended on Wnt pathway by targeting cytoplasmic dishevelled (Dsh or DVL-1) for degradation, lead to nephronophthisis type II, an autosomal recessive cystic kidney disease characterized by extensive renal cysts, situs inversus, and renal failure [20]. Here, INVS is linked to cystic kidney disease.