Furthermore, reduced levels of CSE1L were reported in the post-mortem brains of patients with frontotemporal lobar degeneration (FTLD), the disease which shares many clinical, pathological and genetic characteristics with ALS, including nuclear trafficking impairment as well as in the post-mortem brains of ALS-TDP patients [35,36,37]. The gene discussed is CSE1L; the disease is amyotrophic lateral sclerosis.