Even though the activation of these pathways and the production of these proinflammatory ILs (IL-1β and IL-18) are natural protective measures, long-term chronic inflammation can exhaust the innate immune system and cause insulin resistance, hyperglycemia and lipidemia [28], linking NLRP3 inflammasomes between metabolic and immune responses associated with lipids and glucose metabolism [29]. The gene discussed is IL1B; the disease is Hyperglycemia.