NFE2L2 and Friedreich ataxia: In fact, although FRDA symptoms usually manifest at around 10 ten years of age in patients, lack of FXN can be present since development, and the literature evidence has demonstrated pre-symptomatic neurodevelopmental defects, along with Nrf2 impairments [25,226,227], suggesting that managing FRDA impairments as soon as possible could lead to more favourable outcomes.