LEP and coronary artery disorder: Due to its effects on the cardiovascular system, several studies pointed out how hyperleptinemia may be associated with myocardial infarction in addition to raised leptin levels [91], which have been associated with coronary heart disease [92,93], including a higher risk of cardiac death, nonfatal myocardial infarction, unstable angina, cerebrovascular accident, and heart failure [94].