INS and type 2 diabetes mellitus: In this respect, our observation is entirely consistent with the findings of the Botnia study [36] conducted on 2445 non-diabetic subjects, which describes that those who returned their plasma glucose concentration below FPG within 60 min had increased IS, greater insulin secretion, and lower risk for future T2DM compared to those whose post-load plasma glucose concentration required 120 min or a longer time to return.