Moreover, we found that oral cancer patients with a high co-expression of REEP6/Slug had poor DFS (adjusted hazard ratio (AHR) = 2.69, 95% CI = 1.04–6.95, p = 0.041, Table 3), indicating that REEP6 might be involved in TSCC metastasis. This evidence concerns the gene REEP6 and lip and oral cavity carcinoma.