It is interesting to point out that three miRNAs (miR-146, which has an anti-inflammatory NFκB-dependent function [58,81]; miR-155, which improves skin inflammation, decreasing CTLA-4 expression [54,80]; miR-223, which is expressed by neutrophils, monocytes and eosinophils and has a proinflammatory function [66,78,79]) are found in AD and ACD pathogenesis, suggesting that some of the underlying inflammatory mechanisms might be the same for both diseases. This evidence concerns the gene CTLA4 and granular corneal dystrophy type II.