Based on the existing literature on both the benefits of aerobic exercise on cardiorespiratory health and functionality in patients with hip fractures [17,64], the positive regulation it brings about in biochemical markers such as hypercoagulability [22,23] and albumin [71,72], we hypothesize that a pre- and postoperative exercise program can provide a comprehensive, multidimensional and multisystemic benefit to patients after a hip fracture. The gene discussed is ALB; the disease is thrombophilia.