Furthermore, patients with bronchiectasis, even without RA, have been shown to have increased serum ACPAs compared to healthy controls, suggesting that recurring infections alone might be sufficient for ACPA generation, while ACPA positivity has been connected to a significant difference in high-resolution-computed-tomography-confirmed bronchiectasis and airway thickening [114,115]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.