Since the role of IL-13 polymorphisms as peptide cytokines belonging to the T helper 2 family and coded by the gene IL-13 in the chromosomal location of 5q31.1 in preeclampsia was not yet revealed by experimental investigation [33], this study aimed to investigate the relationship between IL-13 gene polymorphisms and preeclampsia risk. This evidence concerns the gene IL13 and preeclampsia.