Although the high potential of Lactobacillus cultures for trigging a substrate’s pre-digestion during fermentation and producing bioactive peptides able to prevent hyperglycaemia was already proven [58], in this study, it was not observed that an improved DPP-IV inhibitory activity derived from incubation of BSF prepupa samples with selected LAB strains. This evidence concerns the gene DPP4 and Hyperglycemia.