Meanwhile, these chemicals induce hyperglycemia by impairing insulin signaling transduction and disrupting glucose metabolism, increasing the risk of non-alcoholic fatty liver disease in male zebrafish [67], and stimulating the expression of autophagy and inflammatory genes, increasing the levels of triacylglycerol and total cholesterol in male zebrafish liver, and even inducing fibrosis and hepatic apoptosis resulting in nonalcoholic steatohepatitis [68]. The gene discussed is INS; the disease is Hyperglycemia.