The β-glucan, SCP-1 from health food of Sparassis crispa inhibited the activation of microglia and astrocytes in the brains of AD-like mice and down-regulated IL-6, IL-1β, and TNF-α levels, which may be attributed to the fact that SCP-1 significantly increased the expression of ZO-1 and occludin in the colon and decreased LPS levels [86]. Here, TNF is linked to Alzheimer disease.