NLRP3 and Parkinson disease: In conclusion, although further studies will be necessary to confirm these preliminary findings, i.e., measurement of Ca+ flux and NLRP3 mRNA in blood cells, results herein suggest that the combined measurement of circulatory miR-223-3p, miR-7-1-5p, together with an increased concentration of α-Syn, could discriminate between PD patients and HC, possibly indicating these three molecules are useful biomarkers in Parkinson’s disease.