Further RNA sequencing and functional validation revealed that the c-Myc/FOXM1 pathway mediates mydgf-induced cardiomyocyte expansion and the c-Myc/FOXM1 pathway promotes cardiomyocyte proliferation and cardiac regeneration after cardiac injury in neonatal and adult mice, providing potential targets for reversing cardiac remodeling and heart failure [42]. This evidence concerns the gene MYC and heart failure.