PRNP and scrapie: Replacement of the GPI anchor of cellular scrapie prion protein (PrPC) for a transmembrane domain caused its trafficking from lipid rafts to non-raft areas of the PMs and protection of this non-raft version of PrPC against conversion into the misfolded scrapie form (PrPSC) following expression in cultured scrapie-infected neuronal cells [99].