Interestingly, the insulin-/SU-induced GPI-PLC has been shown to be upregulated by glucose in rat adipocytes [204], explaining the positive correlation between hyperglycemia or diabetes and glycated CD59 in blood and arguing for it as a potential biomarker for the prediction, monitoring, prognosis and/or stratification of vascular diabetic late complications. Here, CD59 is linked to diabetes mellitus.