As ZNF277 overexpression is associated with improved prognosis of human cancers according to the Human Protein Atlas Project [98], whereas PRMT3 overexpression appears to be associated with poor prognosis, uncovering the process by which ZNF277 and PRMT3, two C2H2-type zinc finger proteins, compete for uS5 binding is likely to have relevance to cancer biology. The gene discussed is RPS2; the disease is cancer.