Based on the fact that physical activity is beneficial for health [40], the aim of the study was to investigate how two types of 12-week exercise training affected the parameters of body composition, ADIPO concentrations, ADIPO/LEP ratio and IL-8, as well as indicators of insulin resistance in men with MetS and how the tested parameters changed after a 4-week observation without scheduled training. This evidence concerns the gene CXCL8 and metabolic syndrome.