WNK2 and cancer: Both EVs had common pathways, including extracellular matrix (ECM)-receptor interaction; glycosphingolipid biosynthesis-lacto and neolacto series; choline metabolism in cancer; endocytosis; other types of O-glycan biosynthesis; thyroid hormone signaling pathway; mitogen-activated protein kinase (MAPK) signaling pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; proteoglycan in cancer; and focal adhesion (Figure 4A,B).