The vascular hypothesis of AD, which was first proposed over 30 years ago, is based on the notion that the first inciting event in AD pathogenesis is vascular dysregulation, which then initiates a cascade of molecular and neuropathological changes leading to neuronal dysfunction and the onset of AD pathologies, such as amyloid and tau aggregation [23,24,25,26]. Here, MAPT is linked to Alzheimer disease.