MAPT and Alzheimer disease: Several lines of evidence support the presence of vascular contributions to AD pathogenesis including associations of vascular pathology (e.g., arteriolosclerosis, microinfarcts, and CAA) with mechanisms involved in AD pathogenesis, including amyloid and tau aggregation, oxidative stress, mitochondrial dysfunction, and vascular inflammation, which cumulatively contribute to synaptic loss and neurodegeneration [8,9,13,14,15,19,20].