GPX4 and colorectal carcinoma: miR-15a-3p overexpression inhibited GPX4 by binding to the 3′-untranslated region of GPX4, resulting in increased ROS levels, intracellular Fe2+ levels, and malondialdehyde accumulation in vitro and in vivo; this phenomenon suggests that miR-15a-3p inhibits the expression of GPX4 in CRC cells to positively regulate ferroptosis [89].