The A20-binding inhibitor of NF-κB1 (ABIN-1), also known as TNIP1, is a ubiquitin-binding protein that inhibits RIPK1-independent apoptosis, necroptosis, and NF-κB activation, and ABIN-1 deficiency enhances necroptosis-based CRC treatment [115]. The gene discussed is RIPK1; the disease is colorectal carcinoma.