In regard to neurodegeneration, AMPK activation can improve memory retention in models of AD and DM [336], assist with pathways for healthy aging [58], facilitate clearance of Aß [337] and tau [238] in the brain, diminish Aß neurotoxicity [338], and control chronic inflammation in neurodegenerative disorders [61,81,326]. The gene discussed is MAPT; the disease is Alzheimer disease.