In particular, it was shown that TMZ-induced phosphorylation of cPLA2 is connected to cell growth suppression of glioblastoma cells, except for cells with high expression of O-6-methylguanine-DNA methyltransferase (MGMT), which removes methyl groups transferred to DNA by TMZ [33], leading the cells to chemoresistance against the alkylating agent. This evidence concerns the gene MGMT and glioblastoma.