PLA2G4A and central nervous system cancer: It has been demonstrated that lipid remodeling promoted by cPLA2 and polymerase I and transcript release factor (PTRF), whose increase is generally associated with a worse prognosis in glioma patients [29], leads to tumor proliferation and glioblastoma survival by enhancing endocytosis and by promoting mitochondria energy metabolism and adenosine triphosphate (ATP) release [30].